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College of Arts & Sciences
Department of Psychology

Faculty & Staff Directory

James R. Coleman

Distinguished Professor Emeritus
Department of Psychology
University of South Carolina

Office: Barnwell College 241
Phone Number: (803) 777-9526

Dr. Coleman's interests in psychobiology began when he took an undergraduate course in physiological psychology at UCLA. This inclination expanded in graduate school at UCLA as he was able to carry out electrophysiological experiments, and ultimately combine behavioral, electrophysiological and neuroanatomical measures. That experience allowed him to appreciate not only the importance of specific techniques, but also to understand the benefits of combining these methods for attaining a more comprehensive picture in studying brain function. After working in the Brain Research Institute at UCLA and receiving a Ph.D. he worked as a postdoctoral researcher at Duke University for two years. Since arriving at the University of South Carolina he has conducted brain research using a multifold approach which has revealed significant insights into development, organization and repair of the brain.

Dr. Coleman has maintained active memberships in several research societies including the Society for Neuroscience, South Carolina Chapter of Society for Neuroscience, and American Society for Neural Transplantation and Repair. He has served as a regular panel member for the NIH Biomedical Sciences Study Section (International Research Awards) and for the NSF National Research Council in Biomedical Sciences. He is a reviewer for several research journals includingExperimental Neurology, and Journal of Comparative Neurology and Science. His research grants have come from several sources including NIH, NSF and the Deafness Research Foundation.

Dr. Coleman's current research interests follow two primary lines:

  • His major research emphasis involves repair of abnormal or damaged neural circuits. Humans are afflicted with disorders, such as epilepsy, stroke and tumors, which may irreversibly damage brain tissue. Dr. Coleman's laboratory has examined strategies for repairing neural and behavioral deficits using implantation of immature tissues, including genetically engineered cells. These studies demonstrate that these procedures can facilitate recovery from epileptic symptoms and loss of central hearing function.
  • He is also interested in how sensory systems develop and age, and the role played by experience. This work has revealed differential development of the auditory pathways and also demonstrated effects, such as the impact of exposure to an intense sound during a sensitive period, on development of seizure sensitivity.

    Representative Publications:

    Ross, K. C., C. Conero-Goldberg, Freed, W. J., Waldman, B. C., & J. R. Coleman. (2002). Transplantation of M213-20 cells with enhanced GAD67 expression in the inferior colliculus alters audiogenic seizures. Experimental Neurology, 177, 338-340.

    Ross, K. C, J. R. Coleman, & L. S. Jones. (2001). Anti-epileptiform effects of audiogenic seizure priming on in vitro kindling in rat hippocampus. Neuroscience Letters, 299, 234-238.

    Coleman, J. R., C. J. Gibson, Fourqurean, G.D., & K. C. Ross. (2000). Neural graft modulation of audiogenic seizure susceptibility. Experimental Neurology, 164, 139-144.

    Ross, K. C., & J. R. Coleman. (2000). Developmental and genetic audiogenic seizure models: Behavior and biological substrates. Neuroscience and Biobehavioral Reviews, 24, 639-653.

    Coleman, J. R., Ross, K. C., Mullaney, M. M., & Cooper, W. A. (1999). Latency alterations of the auditory brainstem response in audiogenic seizure-prone Long-Evans rats. Epilepsy Research, 33, 31-38.

    Ross, K. C., & Coleman, J. R. (1999). Audiogenic seizures in the developmentally primed Long-Evans rat. Developmental Psychobiology, 34, 303-313.

    Zrull, M. C., & Coleman, J. R. (1997). Effects of tectal grafts on sound localization deficits induced by inferior colliculus lesions in hooded rats. Experimental Neurology, 145, 16-23.